Associations of chemical composition and sources of PM2.5 with lung function of severe asthmatic adults in a low air pollution environment of urban Nagasaki, Japan.

Previous studies have linked ambient PM2.5 to decreased pulmonary function, but the influence of specific chemical elements and emission sources on the severe asthmatic is not well understood. We examined the mass, chemical constituents, and sources of PM2.5 for short-term associations with the pulmonary function of adults with severe asthma in a low air pollution environment in urban Nagasaki, Japan. We recruited 35 asthmatic adults and obtained the daily record of morning peak expiratory flow (PEF) in spring 2014-2016. PM2.5 filters were extracted from an air quality monitoring station (178 days) and measured for 27 chemical elements. Source apportionment was performed using Positive Matrix Factorization (PMF).

We fitted generalized linear model with generalized estimating equation (GEE) method to estimate changes in PEF (from personal monthly maximum) and odds of severe respiratory deterioration (first ≥ 15% PEF reduction within a 1-week interval) associated with mass, constituents, and sources of PM2.5, with adjustment for temperature and relative humidity.

EDTA

GE4011-100G 100 g
EUR 48

EDTA

GE4011-1KG 1 kg
EUR 84

EDTA

GE4011-250G 250 g
EUR 54

EDTA

GE4011-500G 500 g
EUR 64.8

EDTA

GE4011-1 1
EUR 39.4

EDTA

GE4011-100 100
EUR 11.3

EDTA

GE4011-250 250
EUR 16.4

EDTA

GE4011-500 500
EUR 23.8

EDTA 100GM

IB70180 -
EUR 35.58

EDTA 500GM

IB70182 -
EUR 95.13

0.5M EDTA

EDTA-150 150 µL
EUR 15
Description: 0.5M EDTA used for preparation of urine samples for use with the Oxalate Quick Test Strips. Quantity: 150 µL 0.5M EDTA.

0.5M EDTA

E9000-010 100 ml
EUR 88.8

0.5M EDTA

E9000-050 500 ml
EUR 124.8

0.5M EDTA

REDTA-150 150 µL
EUR 19

EDTA Na2

abx082384-500g 500 g
EUR 243.6

100G EDTA

NAT1090 100G
EUR 52.8

500G EDTA

NAT1092 500G
EUR 174

EDTA plasma

90-1009 100 ml
EUR 2433.6
Description: BNP and NT-proBNP free plasma EDTA

Trypsin (-EDTA)

abx098244-100ml 100 ml
EUR 493.2

EDTA Solution

2103-100 each
EUR 164.4

EDTA, AM ester

19010 10x50 ug
EUR 109

EDTA, AM ester

19011 10 mg
EUR 166

EDTA, AM ester

19010-10x50ug 10x50 ug
EUR 109
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA, AM ester

19011-10mg 10 mg
EUR 166
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA Free Acid

40500020-1 500 g
EUR 34.22

EDTA Free Acid

40500020-2 1 kg
EUR 58.79

EDTA, Free Acid

A2504-500G 500G
EUR 27
Description: Ultra Pure

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-010 100ml
EUR 91.2

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-050 500ml
EUR 100.8

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-101 1L
EUR 151.2

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8150-050 500 ml
EUR 100.8

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8150-801 8L
EUR 144

0.5% EDTA Solution

PB180620-100mL 100 mL
EUR 30
Description: Supplements & Reagents

Rabbit Plasma (EDTA)

88R-1029E 500 ml
EUR 276
Description: Sterile Rabbit Plasma with EDTA

EDTA 10X, pH 8.5

40125009-1 100 mL
EUR 36.77

EDTA 10X, pH 8.5

40125009-2 500 mL
EUR 76.66

CK PLASMA NS EDTA 500mL

33141-1 500mL
EUR 221.56

Pig PLASMA NS EDTA 500mL

39541-1 500mL
EUR 221.56

EDTA 200mM, pH 8, Sterile

40120781-1 6x500 mL
EUR 190.33

USP Sol. EDTA TS

USP2401 100ML
EUR 30

USP Sol. EDTA TS

USP2405 500ML
EUR 48

EDTA SOL. (0.5M) PH8.0

IB70184 100ML
EUR 31.01

EDTA SOL. (0.5M) PH8.0

IB70186 1L
EUR 59.3

EDTA SOL. (0.5M) PH8.0

IB70187 10L
EUR 203.4

PEGylated Liposomal EDTA

PHPC002EDTA 2 ml
EUR 140.62
Description: This product includes 2 ml of 30 mM EDTA encapsulated in 6 mg/ml liposomes in 0.1 M NaCl.

Rabbit PLASMA NS EDTA 500mL

31141-1 500mL
EUR 314.21

Rabbit PLASMA S EDTA 500mL

31156-1 500mL
EUR 342.91

Bovine PLASMA NS EDTA 500mL

37141-1 500mL
EUR 221.56

EDTA Tetrasodium Anhydrous

40500043-1 500 g
EUR 31.76

EDTA Tetrasodium Anhydrous

40500043-2 1 kg
EUR 52.61

CP 0.1M EDTA Solution

CP8011 1L
EUR 27.6

1L EDTA 0.5M Solution

NAT1282 1L
EUR 183.6

EDTA, Ultra Pure, 1kg

R9410-1kg each
EUR 228

EDTA, Ultra Pure, 1kg

R9410 1kg
EUR 121.44

Coagplas Rab Edta 3M

240827 PK10
EUR 95.31

RIPA Buffer with EDTA

42020004-1 250 mL
EUR 38.57

RIPA Buffer with EDTA

42020004-2 500 mL
EUR 65.49

CK WH BLOOD NS EDTA 500mL*

33131-1 500mL
EUR 282.89

Pig WH BLOOD NS EDTA 500mL*

39531-1 500mL
EUR 242.44

0.5 M EDTA, pH 8.0

GR103066 100 mL
EUR 69

EDTA ferric sodium salt

GE7700-100G 100 g
EUR 52.8

EDTA ferric sodium salt

GE7700-1KG 1 kg
EUR 117.6

EDTA ferric sodium salt

GE7700-250G 250 g
EUR 64.8

EDTA ferric sodium salt

GE7700-500G 500 g
EUR 84

EDTA ferric sodium salt

GE7700-1 1
EUR 67.2

EDTA ferric sodium salt

GE7700-100 100
EUR 15.7

EDTA ferric sodium salt

GE7700-250 250
EUR 23.8

EDTA ferric sodium salt

GE7700-500 500
EUR 39.4

EDTA 0.5M Sterile Solution

SD8135 450ml
EUR 86.1

EDTA Titrant Buffer 10mM

40170017-1 500 mL
EUR 21.41
Description: Ethylenediaminetetraacetic Acid

USP Sol. 0.1 M EDTA

USP10115 500ML
EUR 60

Normal Feline Plasma (EDTA)

abx098254-50ml 50 ml
EUR 844.8

MicroMolar EDTA Assay kit

EDTA200 200 assays
EUR 221.78
Description: This product includes 200 ul of 100 x C56 dye and 1000 ul of 1 mM EDTA. It is for measurement of 200 samples using 96-well plates. Cuvettes may also be used for measurements.

100mL 0.5M EDTA pH 8.0

46-034-CI EACH
EUR 57.6

EDTA Buffer, 1X pH 8.0

18-155 500ml/Unit
EUR 380

EDTA Buffer, 1X pH 8.0

18-156 1000ml/Unit
EUR 427

EDTA, Disodium Salt, Dihydrate

CH032 500 g
EUR 195.6

EDTA, Disodium Salt, Dihydrate

CH033 1.0 kg
EUR 234

EDTA, Disodium Salt, Dihydrate

CH034 2.5 kg
EUR 400.8

EDTA disodium salt dihydrate

GE3023-100G 100 g
EUR 48

EDTA disodium salt dihydrate

GE3023-1KG 1 kg
EUR 84

EDTA disodium salt dihydrate

GE3023-250G 250 g
EUR 55.2

EDTA disodium salt dihydrate

GE3023-500G 500 g
EUR 64.8

EDTA disodium salt dihydrate

GE3023-5KG 5 kg
EUR 180

EDTA, disodium salt, dihydrate

EB0185 500g
EUR 84.01

EDTA Disodium Salt Dihydrate

40500012-1 500 g
EUR 53.99

EDTA Disodium Salt Dihydrate

40500012-2 1 kg
EUR 89.15

EDTA Disodium Salt Dihydrate

40500012-3 2.5 kg
EUR 187.43

EDTA Disodium Salt Dihydrate

40500012-4 5 kg
EUR 319.37

EDTA Disodium Salt Dihydrate

40500012-5 10 kg
EUR 621.34

EDTA, Disodium Salt, Dihydrate

A2503-1KG 1KG
EUR 46.2
Description: Biotechnology

EDTA, Disodium Salt, Dihydrate

A2503-500G 500G
EUR 26.4
Description: Biotechnology

EDTA, Disodium Salt, Dihydrate

A2503-5KG 5KG
EUR 189.2
Description: Biotechnology

EDTA disodium salt dihydrate

GE3023-1 1
EUR 39.4

EDTA disodium salt dihydrate

GE3023-100 100
EUR 11.3

EDTA disodium salt dihydrate

GE3023-250 250
EUR 15.9

EDTA disodium salt dihydrate

GE3023-5 5
EUR 118.7

EDTA disodium salt dihydrate

GE3023-500 500
EUR 23.8

EDTA 17% pH 7.0, Sterile

40120337-1 100 mL
EUR 15.1

EDTA 17% pH 7.0, Sterile

40120337-2 250 ml
EUR 22.6

EDTA 0.5M, pH 9.0, Sterile

40120778-1 100 mL
EUR 36.77

EDTA 0.5M, pH 9.0, Sterile

40120778-2 250 mL
EUR 49.42

EDTA 0.5M, pH 9.0, Sterile

40120778-3 500 mL
EUR 69.32

EDTA 0.5M, pH 9.0, Sterile

40120778-4 1 L
EUR 102.65

EDTA 0.5M, pH 7.5, Sterile

40120779-1 100 mL
EUR 36.77

EDTA 0.5M, pH 7.5, Sterile

40120779-2 250 mL
EUR 49.42

EDTA 0.5M, pH 7.5, Sterile

40120779-3 500 mL
EUR 70.46

EDTA 0.5M, pH 7.5, Sterile

40120779-4 1 L
EUR 128.98

EDTA 0.5M, pH 7.5, Sterile

40120779-5 10x100 mL
EUR 252.56

EDTA 0.5M, pH 8.0, Sterile

40520000-1 100 mL
EUR 39.49

EDTA 0.5M, pH 8.0, Sterile

40520000-2 500 mL
EUR 69.32

EDTA 0.5M, pH 8.0, Sterile

40520000-3 1 L
EUR 114.21

EDTA 0.5M, pH 8.0, Sterile

40520000-4 250 mL
EUR 49.42

EDTA 0.5M, pH 8.0, Sterile

40520000-5 100 mL
EUR 92.12

EDTA tetrasodium salt hydrate

GE3450-100G 100 g
EUR 49.2

EDTA tetrasodium salt hydrate

GE3450-1KG 1 kg
EUR 81.6

EDTA tetrasodium salt hydrate

GE3450-250G 250 g
EUR 54

EDTA tetrasodium salt hydrate

GE3450-500G 500 g
EUR 63.6

EDTA tetrasodium salt hydrate

GE3450-5KG 5 kg
EUR 199.2

EDTA trisodium salt dihydrate

GE9701-100G 100 g
EUR 64.8

EDTA trisodium salt dihydrate

GE9701-250G 250 g
EUR 93.6

EDTA trisodium salt dihydrate

GE9701-500G 500 g
EUR 141.6

EDTA tetrasodium salt hydrate

GE3450-1 1
EUR 38

EDTA tetrasodium salt hydrate

GE3450-100 100
EUR 11.8

EDTA tetrasodium salt hydrate

GE3450-250 250
EUR 16.4

EDTA tetrasodium salt hydrate

GE3450-5 5
EUR 134.4

EDTA tetrasodium salt hydrate

GE3450-500 500
EUR 22.9

EDTA trisodium salt dihydrate

GE9701-100 100
EUR 23.8

EDTA trisodium salt dihydrate

GE9701-250 250
EUR 47.4

EDTA trisodium salt dihydrate

GE9701-500 500
EUR 87.1

EDTA Solution 1.62% w/v

EDTA1625 5L
EUR 180

EDTA SOL. (0.5M) pH8.0 4x100ML

IB70185 -
EUR 88.53
Description: (MADE FROM (4) IB70184)

EDTA tetrasodium salt dihydrate

GK0795-100G 100 g
EUR 48

EDTA tetrasodium salt dihydrate

GK0795-1KG 1 kg
EUR 84

EDTA tetrasodium salt dihydrate

GK0795-2500G 2500 g
EUR 141.6

EDTA tetrasodium salt dihydrate

GK0795-250G 250 g
EUR 55.2

EDTA tetrasodium salt dihydrate

GK0795-500G 500 g
EUR 63.6

EDTA dipotassium salt dihydrate

GE5635-100G 100 g
EUR 64.8

EDTA dipotassium salt dihydrate

GE5635-250G 250 g
EUR 88.8

EDTA dipotassium salt dihydrate

GE5635-500G 500 g
EUR 122.4

EDTA, tetrasodium salt dihydrate

EB0436 500g
EUR 105.94

EDTA, dipotassium salt, dihydrate

ED0075 250g
EUR 99.67

EDTA Dipotassium Salt Dihydrate

40500008-1 500 g
EUR 89.9

EDTA Dipotassium Salt Dihydrate

40500008-2 1 kg
EUR 179.81

EDTA Tetrasodium Salt Dihydrate

40500024-1 500 g
EUR 53.98

EDTA Tetrasodium Salt Dihydrate

40500024-2 1 kg
EUR 90.14

EDTA Tetrasodium Salt Dihydrate

40500024-3 2.5 kg
EUR 173.72

EDTA Tetrasodium Salt Dihydrate

40500024-4 5 kg
EUR 298.32

EDTA Tetrasodium Salt Dihydrate

40500024-5 50 kg
EUR 2745.23

EDTA dipotassium salt dihydrate

GE5635-100 100
EUR 23.8

EDTA dipotassium salt dihydrate

GE5635-250 250
EUR 43.5

EDTA dipotassium salt dihydrate

GE5635-500 500
EUR 71.1

EDTA tetrasodium salt dihydrate

GK0795-1 1
EUR 39.4

EDTA tetrasodium salt dihydrate

GK0795-100 100
EUR 11.3

EDTA tetrasodium salt dihydrate

GK0795-250 250
EUR 15.9

EDTA tetrasodium salt dihydrate

GK0795-2500 2500
EUR 87.1

EDTA tetrasodium salt dihydrate

GK0795-500 500
EUR 22.9

PBS Buffer 10X with EDTA

41620018-1 1 L
EUR 32.46

PBS Buffer 10X with EDTA

41620018-2 2 L
EUR 51.77

PBS Buffer 10X with EDTA

41620018-3 6 L
EUR 120.2

EDTA tripotassium salt dihydrate

GL1464-100G 100 g
EUR 73.2

EDTA tripotassium salt dihydrate

GL1464-250G 250 g
EUR 103.2

EDTA tripotassium salt dihydrate

GL1464-25G 25 g
EUR 52.8

EDTA tripotassium salt dihydrate

GL1464-500G 500 g
EUR 153.6

EDTA tripotassium salt dihydrate

GL1464-100 100
EUR 30.9

EDTA tripotassium salt dihydrate

GL1464-25 25
EUR 15.7

EDTA tripotassium salt dihydrate

GL1464-250 250
EUR 55.4

EDTA tripotassium salt dihydrate

GL1464-500 500
EUR 97.3

EDTA, Iron (III), sodium salt

EB0437 100g
EUR 78.79

EDTA solution, 0.5M in water

GE5993-500 500
EUR 17.7

EDTA solution, 0.1M in water

GE7722-500 500
EUR 16.6

Rabbit WH BLOOD NS EDTA YG 500mL*

31131-1 500mL
EUR 314.21

Bovine MT WH BLOOD NS EDTA 500mL*

37131-1 500mL
EUR 242.44

Rabbit PLASMA NS K2 EDTA Y 500mL

31144-1 500mL
EUR 314.21

Rabbit PLASMA NS K3 EDTA YG 500mL

31145-1 500mL
EUR 280.27

EDTA zinc (II), disodium salt

EB6666 100g
EUR 77.75

EDTA Disodium Salt 0.02m (0.04n)

ED20021 1L
EUR 157.2

RIPA Buffer with EDTA & EGTA

42020008-1 250 mL
EUR 32.26

RIPA Buffer with EDTA & EGTA

42020008-2 500 mL
EUR 53.3

TBS with EDTA 5X, pH 7.4

42020388-1 1 L
EUR 36.23

TBS with EDTA 5X, pH 7.4

42020388-2 2 L
EUR 62.69

TBS with EDTA 5X, pH 7.4

42020388-3 4 L
EUR 111.42

TBS with EDTA 5X, pH 7.4

42020388-4 500 mL
EUR 25.9

EDTA copper(II) disodium salt

EB0434 250g
EUR 100.72

0.25%Trypsin-0.04%EDTA Solution

TEDTA-10001 100mL
EUR 49

EDTA buffer pH 8.0, 1000 ml

12-9160-5 1000 ml
EUR 315.6

EDTA buffer pH 8.0, 500 ml

12-9161-5 500 ml
EUR 236.4

EDTA 0.5 M, pH 8.0, Sterile

40120780-1 200 mL
EUR 272.69

Dog Plasma (Sterile Sodium EDTA)

20-abx800113
  • EUR 1680.00
  • EUR 3951.60
  • EUR 1296.00
  • 100 ml
  • 500 ml
  • 50 ml

Dog Plasma (Sterile Sodium EDTA)

abx800113-1L 1 L
EUR 6824.4

Goat Plasma (Sterile Sodium EDTA)

20-abx800038
  • EUR 794.40
  • EUR 994.80
  • EUR 678.00
  • 100 ml
  • 500 ml
  • 50 ml

Goat Plasma (Sterile Sodium EDTA)

abx800038-1L 1 L
EUR 1195.2

EDTA disodium zinc salt hydrate

GX3802-100G 100 g
EUR 64.8

EDTA disodium zinc salt hydrate

GX3802-250G 250 g
EUR 90

EDTA disodium zinc salt hydrate

GX3802-25G 25 g
EUR 51.6

EDTA disodium zinc salt hydrate

GX3802-500G 500 g
EUR 132

EDTA disodium zinc salt hydrate

GX3802-100 100
EUR 23.8

EDTA disodium zinc salt hydrate

GX3802-25 25
EUR 13.9

EDTA disodium zinc salt hydrate

GX3802-250 250
EUR 44.3

Constituent sulfate (SO42-) and PM2.5 from oil combustion and traffic were associated with reduced PEF. An interquartile range (IQR) increase in SO42- (3.7 μg/m3, average lags 0-1) was associated with a decrease of 0.38% (95% confidence interval = -0.75% to -0.001%). An IQR increase in oil combustion and traffic-sourced PM2.5 (2.64 μg/m3, lag 1) was associated with a decrease of 0.33% (-0.62% to -0.002%).

We found a larger PEF decrease associated with PM2.5 from dust/soil on Asian Dust days. There was no evidence linking total mass and metals to reduced pulmonary function. The ventilatory capacity of adults with severe asthma is susceptible to specific constituents/sources of PM2.5 such as sulfate and oil combustion and traffic despite active self-management of asthma and low air pollution levels in the study location.