Associations of chemical composition and sources of PM2.5 with lung function of severe asthmatic adults in a low air pollution environment of urban Nagasaki, Japan.

Previous studies have linked ambient PM2.5 to decreased pulmonary function, but the influence of specific chemical elements and emission sources on the severe asthmatic is not well understood. We examined the mass, chemical constituents, and sources of PM2.5 for short-term associations with the pulmonary function of adults with severe asthma in a low air pollution environment in urban Nagasaki, Japan. We recruited 35 asthmatic adults and obtained the daily record of morning peak expiratory flow (PEF) in spring 2014-2016. PM2.5 filters were extracted from an air quality monitoring station (178 days) and measured for 27 chemical elements. Source apportionment was performed using Positive Matrix Factorization (PMF).

We fitted generalized linear model with generalized estimating equation (GEE) method to estimate changes in PEF (from personal monthly maximum) and odds of severe respiratory deterioration (first ≥ 15% PEF reduction within a 1-week interval) associated with mass, constituents, and sources of PM2.5, with adjustment for temperature and relative humidity.

EDTA

B7197-1000 1 g
EUR 62
Description: A chelating agent

EDTA

GE4011 100g
EUR 36.1

EDTA

GE4011-1 1
EUR 39.4

EDTA

GE4011-100 100
EUR 11.3

EDTA

GE4011-100G 100 g
EUR 48

EDTA

GE4011-1KG 1 kg
EUR 84

EDTA

GE4011-250 250
EUR 16.4

EDTA

GE4011-250G 250 g
EUR 54

EDTA

GE4011-500 500
EUR 23.8

EDTA

GE4011-500G 500 g
EUR 64.8

EDTA

abx082228-100l 100 µl
EUR 125

EDTA

abx082228-1ml 1 ml Ask for price

EDTA

abx082228-200l 200 µl
EUR 187.5

EDTA 100GM

IB70180 -
EUR 35.58

EDTA 500GM

IB70182 -
EUR 95.13

EDTA Magnesium Disodium Complex (EDTA Mg) pure

41000 100 Gms
EUR 1.37
Description: Part A

0.5M EDTA

EDTA-150 150 µL
EUR 15
Description: 0.5M EDTA used for preparation of urine samples for use with the Oxalate Quick Test Strips. Quantity: 150 µL 0.5M EDTA.

0.5M EDTA

E9000-010 100 ml
EUR 88.8

0.5M EDTA

E9000-050 500 ml
EUR 124.8

0.5M EDTA

CH124 500 ml
EUR 105
Description: Ethylenediaminetetraacetic acid (EDTA) is a solution that inactivates enzymes. At a chemical level, it forms coordination compounds with metal ions, causing them to inactivate.

0.5M EDTA

REDTA-150 150 µL
EUR 19

EDTA, 1%

RK-EDTA 5 ml
EUR 18.36

EDTA Na2

abx082384-500g 500 g
EUR 243.6

EDTA Na2

abx082384-100l 100 µl
EUR 125

EDTA Na2

abx082384-1ml 1 ml Ask for price

EDTA Na2

abx082384-200l 200 µl Ask for price

100G EDTA - 100G

NAT1090 100G
EUR 59.4

500G EDTA - 500G

NAT1092 500G
EUR 195.75

EDTA plasma

90-1009 100 ml
EUR 2589
Description: BNP and NT-proBNP free plasma EDTA

Trypsin (-EDTA)

abx098244-100ml 100 ml
EUR 493.2

EDTA Solution

2103-100 each
EUR 164.4

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-010 100ml
EUR 91.2

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-050 500ml
EUR 100.8

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8059-101 1L
EUR 151.2

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8150-050 500 ml
EUR 100.8

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8150-801 8L
EUR 144

EDTA, AM ester

19010 10x50 ug
EUR 112
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA, AM ester

19010-10x50ug 10x50 ug
EUR 109
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA, AM ester

19011 10 mg
EUR 170
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA, AM ester

19011-10mg 10 mg
EUR 166
Description: Ethylenediaminetetraacetic acid (EDTA) might be the most popular metal ion chelator used for both industrial and medical purposes.

EDTA Buffer, 1X

18-155 500ml/Unit
EUR 186.76
Description: pH 8.0

EDTA Buffer, 1X

18-156 1000ml/Unit
EUR 298.7
Description: pH 8.0

EDTA Free Acid

40500020-1 500 g
EUR 34.22

EDTA Free Acid

40500020-2 1 kg
EUR 58.79

EDTA, Free Acid

A2504-500G 500G
EUR 27
Description: Ultra Pure

GVBE (with EDTA)*

B104 250 mL
EUR 92

GVBE (with EDTA)*

B105 1 L
EUR 246

0.5% EDTA Solution

PB180620-100mL 100 mL
EUR 30
Description: Supplements & Reagents

Sodium Iron EDTA

S634990 100g
EUR 219
Description: 15708-41-5

EDTA Solution (0.5M)

TBS5040 100 ml
EUR 26

0.5% EDTA Solution

PB180620 100mL
EUR 30
Description: Dissociation reagent

TRIS EDTA BUFFER

T855 100G
EUR 170.44

0.5% EDTA Solution

MBS2570190-100mL 100mL
EUR 100

0.5% EDTA Solution

MBS2570190-5x100mL 5x100mL
EUR 435

EDTA (iron sodium)

HY-131926 100 g
EUR 71.43
Description: EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Rabbit Plasma (EDTA)

88R-1029E 500 ml
EUR 137
Description: Sterile Rabbit Plasma with EDTA

EDTA, DISODIUM SALT

E410 100G
EUR 78.89

Rabbit Plasma (EDTA)

MBS837790-100mL 100mL
EUR 670

Rabbit Plasma (EDTA)

MBS837790-500mL 500mL
EUR 1460

Rabbit Plasma (EDTA)

MBS837790-5x500mL 5x500mL
EUR 6350

Trypsin EDTA (Powder)

MBS652969-10L 10L
EUR 265

Trypsin EDTA (Powder)

MBS652969-25L 25L
EUR 435

Trypsin EDTA (Powder)

MBS652969-50L 50L
EUR 625

Trypsin EDTA (Powder)

MBS652969-5x50L 5x50L
EUR 2190

10 × EDTA Anticoagulant

E-EL-SR003-24Tests 24 Tests Ask for price

10 × EDTA Anticoagulant

E-EL-SR003-48Tests 48 Tests Ask for price

10 × EDTA Anticoagulant

E-EL-SR003-96Tests 96 Tests
EUR 6

10 × EDTA Anticoagulant

E-EL-SR003-96Tests10 96 Tests *10
EUR 60

10 × EDTA Anticoagulant

E-EL-SR003-96Tests5 96 Tests *5
EUR 30

USP Sol. EDTA TS - 100ML

USP2401 100ML
EUR 33.75

USP Sol. EDTA TS - 500ML

USP2405 500ML
EUR 54

0.5M EDTA pH 8.0

ML014-100ML 1 unit
EUR 14.75
Description: 0.5M EDTA pH 8.0

0.5M EDTA pH 8.0

ML014-500ML 1 unit
EUR 43.09
Description: 0.5M EDTA pH 8.0

PEGylated Liposomal EDTA

PHPC002EDTA 2 ml
EUR 140.62
Description: This product includes 2 ml of 30 mM EDTA encapsulated in 6 mg/ml liposomes in 0.1 M NaCl.

EDTA 200mM, pH 8, Sterile

40120781-1 6x500 mL
EUR 190.33

EDTA 10X, pH 8.5

40125009-1 100 mL
EUR 36.77

EDTA 10X, pH 8.5

40125009-2 500 mL
EUR 76.66

EDTA SOL. (0.5M) PH8.0

IB70184 100ML
EUR 31.01

EDTA SOL. (0.5M) PH8.0

IB70186 1L
EUR 59.3

EDTA SOL. (0.5M) PH8.0

IB70187 10L
EUR 203.4

EDTA Tetrasodium Anhydrous

40500043-1 500 g
EUR 31.76

EDTA Tetrasodium Anhydrous

40500043-2 1 kg
EUR 52.61

EDTA Decalcification Solution

MBS2567127-100mL 100mL
EUR 95

EDTA Decalcification Solution

MBS2567127-1L 1L
EUR 175

EDTA Decalcification Solution

MBS2567127-500mL 500mL
EUR 135

EDTA Decalcification Solution

MBS2567127-5x1L 5x1L
EUR 745

EDTA, Ultra Pure, 1kg

R9410 1kg
EUR 121.44

EDTA, Ultra Pure, 1kg

R9410-1kg each
EUR 228

RIPA Buffer with EDTA

42020004-1 250 mL
EUR 47.3

RIPA Buffer with EDTA

42020004-2 500 mL
EUR 80.32

USP Sol. 0.1 M EDTA - 500ML

USP10115 500ML
EUR 67.5

EDTA Disodium Salt, 0.25M

MBS635394-100mL 100mL
EUR 145

EDTA Disodium Salt, 0.25M

MBS635394-1L 1L
EUR 310

EDTA Disodium Salt, 0.25M

MBS635394-25L 2.5L
EUR 590

EDTA Disodium Salt, 0.25M

MBS635394-4L 4L
EUR 910

EDTA Disodium Salt, 0.25M

MBS635394-500mL 500mL
EUR 220

CK WH BLOOD NS EDTA 500mL*

33131-1 500mL
EUR 282.89

Pig WH BLOOD NS EDTA 500mL*

39531-1 500mL
EUR 242.44

EDTA ferric sodium salt

GE7700 100g
EUR 61.56

EDTA ferric sodium salt

GE7700-1 1
EUR 67.2

EDTA ferric sodium salt

GE7700-100 100
EUR 15.7

EDTA ferric sodium salt

GE7700-100G 100 g
EUR 52.8

EDTA ferric sodium salt

GE7700-1KG 1 kg
EUR 117.6

EDTA ferric sodium salt

GE7700-250 250
EUR 23.8

EDTA ferric sodium salt

GE7700-250G 250 g
EUR 64.8

EDTA ferric sodium salt

GE7700-500 500
EUR 39.4

EDTA ferric sodium salt

GE7700-500G 500 g
EUR 84

TRIS BORATE EDTA BUFFER

T831 100G
EUR 129.02

EDTA Titrant Buffer 10mM

40170017-1 500 mL
EUR 21.41

Coagulase Plasma w/ EDTA

FD248A-2X5VL 1 unit
EUR 129.09
Description: Coagulase Plasma w/ EDTA

Coagulase Plasma w/ EDTA

FD248A-5VL 1 unit
EUR 71.58
Description: Coagulase Plasma w/ EDTA

EDTA 0.5M Sterile Solution

SD8135 450ml
EUR 86.1

0.5 M EDTA, pH 8.0

GR103066 100 mL
EUR 69

0.5 M EDTA pH 8.0

E0240-01 100ml
EUR 19.62

0.5 M EDTA pH 8.0

E0240-02 500ml
EUR 30.52

0.5 M EDTA pH 8.0

E0240-03 1l
EUR 54.5

Normal Feline Plasma (EDTA)

abx098254-50ml 50 ml
EUR 844.8

EDTA disodium barium salt

E00170 10G
EUR 190.9

MicroMolar EDTA Assay kit

EDTA200 200 assays
EUR 221.78
Description: This product includes 200 ul of 100 x C56 dye and 1000 ul of 1 mM EDTA. It is for measurement of 200 samples using 96-well plates. Cuvettes may also be used for measurements.

EDTA disodium calcium salt

E00190 25G
EUR 116.35

EDTA calcium disodium salt

GRM1371-500G 1 unit
EUR 17.53
Description: EDTA calcium disodium salt

Imipenem with & ?without EDTA

EM078-10ST 1 unit
EUR 26.2
Description: Imipenem with & ?without EDTA

EDTA ferric monosodium salt

GRM1197-100G 1 unit
EUR 6.93
Description: EDTA ferric monosodium salt

EDTA ferric monosodium salt

GRM1197-500G 1 unit
EUR 12.6
Description: EDTA ferric monosodium salt

Meropenem with & without EDTA

EM092-120ST 1 unit
EUR 171.01
Description: Meropenem with & without EDTA

Meropenem with & without EDTA

EM092-150ST 1 unit
EUR 203.7
Description: Meropenem with & without EDTA

Meropenem with & without EDTA

EM092-30ST 1 unit
EUR 60.62
Description: Meropenem with & without EDTA

Meropenem with & without EDTA

EM092-60ST 1 unit
EUR 109.13
Description: Meropenem with & without EDTA

Meropenem with & without EDTA

EM092-90ST 1 unit
EUR 147.14
Description: Meropenem with & without EDTA

EDTA, Disodium Dihydrate Salt

20-147 500g/Unit
EUR 73.04
Description: Ultra Pure Grade

EDTA Disodium Salt Dihydrate

40500012-1 500 g
EUR 53.99

EDTA Disodium Salt Dihydrate

40500012-2 1 kg
EUR 89.15

EDTA Disodium Salt Dihydrate

40500012-3 2.5 kg
EUR 187.43

EDTA Disodium Salt Dihydrate

40500012-4 5 kg
EUR 319.37

EDTA Disodium Salt Dihydrate

40500012-5 10 kg
EUR 621.34

EDTA disodium manganous salt

E00240 25G
EUR 257.58

EDTA, disodium salt, dihydrate

EB0185 500g
EUR 84.01

EDTA, Disodium Salt, Dihydrate

CH032 500 g
EUR 195.6

EDTA, Disodium Salt, Dihydrate

CH033 1.0 kg
EUR 130
Description: A reversible metalloprotease inhibitor useful for chelating metal ions.

EDTA, Disodium Salt, Dihydrate

CH034 2.5 kg
EUR 400.8

EDTA, Disodium Salt, Dihydrate

A2503-1KG 1KG
EUR 46.2
Description: Biotechnology

EDTA, Disodium Salt, Dihydrate

A2503-500G 500G
EUR 26.4
Description: Biotechnology

EDTA, Disodium Salt, Dihydrate

A2503-5KG 5KG
EUR 189.2
Description: Biotechnology

EDTA disodium salt dihydrate

GRM1195-100G 1 unit
EUR 6.93
Description: EDTA disodium salt dihydrate

EDTA disodium salt dihydrate

GRM1195-1KG 1 unit
EUR 25.12
Description: EDTA disodium salt dihydrate

EDTA disodium salt dihydrate

GRM1195-500G 1 unit
EUR 13.97
Description: EDTA disodium salt dihydrate

EDTA disodium salt dihydrate

GE3023 100g
EUR 108.65

EDTA disodium salt dihydrate

GE3023-1 1
EUR 39.4

EDTA disodium salt dihydrate

GE3023-100 100
EUR 11.3

EDTA disodium salt dihydrate

GE3023-100G 100 g
EUR 48

EDTA disodium salt dihydrate

GE3023-1KG 1 kg
EUR 84

EDTA disodium salt dihydrate

GE3023-250 250
EUR 15.9

EDTA disodium salt dihydrate

GE3023-250G 250 g
EUR 55.2

EDTA disodium salt dihydrate

GE3023-5 5
EUR 118.7

EDTA disodium salt dihydrate

GE3023-500 500
EUR 23.8

EDTA disodium salt dihydrate

GE3023-500G 500 g
EUR 64.8

EDTA disodium salt dihydrate

GE3023-5KG 5 kg
EUR 180

EDTA Disodium Salt Dihydrate

MBS635343-100g 100g
EUR 155

EDTA Disodium Salt Dihydrate

MBS635343-1kg 1kg
EUR 320

EDTA Disodium Salt Dihydrate

MBS635343-25kg 2.5kg
EUR 690

EDTA Disodium Salt Dihydrate

MBS635343-500g 500g
EUR 260

EDTA Disodium Salt Dihydrate

MBS635343-5kg 5kg
EUR 1020

EDTA, Disodium Salt, Dihydrate

MBS4156372-500g 500g
EUR 260

EDTA, Disodium Salt, Dihydrate

MBS4156372-5x500g 5x500g
EUR 920

EDTA, Disodium Salt, Dihydrate

MBS4156373-1kg 1kg
EUR 285

EDTA, Disodium Salt, Dihydrate

MBS4156373-5x1kg 5x1kg
EUR 1095

EDTA, Disodium Salt, Dihydrate

MBS4156374-25kg 2.5kg
EUR 465

EDTA, Disodium Salt, Dihydrate

MBS4156374-5x25kg 5x2.5kg
EUR 1705

10X Tris EDTA, pH 9.0

ML087-500ML 1 unit
EUR 11.87
Description: 10X Tris EDTA, pH 9.0

EDTA tetrasodium salt hydrate

GE3450 100g
EUR 123.04

EDTA trisodium salt dihydrate

GE9701 100g
EUR 79.7

EDTA tetrasodium salt hydrate

GE3450-1 1
EUR 38

EDTA tetrasodium salt hydrate

GE3450-100 100
EUR 11.8

EDTA tetrasodium salt hydrate

GE3450-100G 100 g
EUR 49.2

EDTA tetrasodium salt hydrate

GE3450-1KG 1 kg
EUR 81.6

EDTA tetrasodium salt hydrate

GE3450-250 250
EUR 16.4

EDTA tetrasodium salt hydrate

GE3450-250G 250 g
EUR 54

EDTA tetrasodium salt hydrate

GE3450-5 5
EUR 134.4

EDTA tetrasodium salt hydrate

GE3450-500 500
EUR 22.9

EDTA tetrasodium salt hydrate

GE3450-500G 500 g
EUR 63.6

EDTA tetrasodium salt hydrate

GE3450-5KG 5 kg
EUR 199.2

EDTA trisodium salt dihydrate

GE9701-100 100
EUR 23.8

EDTA trisodium salt dihydrate

GE9701-100G 100 g
EUR 64.8

EDTA trisodium salt dihydrate

GE9701-250 250
EUR 47.4

EDTA trisodium salt dihydrate

GE9701-250G 250 g
EUR 93.6

EDTA trisodium salt dihydrate

GE9701-500 500
EUR 87.1

EDTA trisodium salt dihydrate

GE9701-500G 500 g
EUR 141.6

EDTA Trisodium Salt Trihydrate

MBS638943-1kg 1kg
EUR 385

EDTA Trisodium Salt Trihydrate

MBS638943-500g 500g
EUR 320

EDTA Trisodium Salt Trihydrate

MBS638943-5x1kg 5x1kg
EUR 1640

EDTA 17% pH 7.0, Sterile

40120337-1 100 mL
EUR 15.1

EDTA 17% pH 7.0, Sterile

40120337-2 250 ml
EUR 22.6

EDTA 0.5M, pH 9.0, Sterile

40120778-1 100 mL
EUR 36.77

EDTA 0.5M, pH 9.0, Sterile

40120778-2 250 mL
EUR 49.42

EDTA 0.5M, pH 9.0, Sterile

40120778-3 500 mL
EUR 69.32

EDTA 0.5M, pH 9.0, Sterile

40120778-4 1 L
EUR 102.65

EDTA 0.5M, pH 7.5, Sterile

40120779-1 100 mL
EUR 36.77

EDTA 0.5M, pH 7.5, Sterile

40120779-2 250 mL
EUR 49.42

EDTA 0.5M, pH 7.5, Sterile

40120779-3 500 mL
EUR 70.46

Constituent sulfate (SO42-) and PM2.5 from oil combustion and traffic were associated with reduced PEF. An interquartile range (IQR) increase in SO42- (3.7 μg/m3, average lags 0-1) was associated with a decrease of 0.38% (95% confidence interval = -0.75% to -0.001%). An IQR increase in oil combustion and traffic-sourced PM2.5 (2.64 μg/m3, lag 1) was associated with a decrease of 0.33% (-0.62% to -0.002%).

We found a larger PEF decrease associated with PM2.5 from dust/soil on Asian Dust days. There was no evidence linking total mass and metals to reduced pulmonary function. The ventilatory capacity of adults with severe asthma is susceptible to specific constituents/sources of PM2.5 such as sulfate and oil combustion and traffic despite active self-management of asthma and low air pollution levels in the study location.